Bone Abstracts

Skeletal development during childhood and adolescence is an important determinant of adult bone health. Patterns of growth differ between populations, but it is unclear how these differences relate to changes in bone size and volumetric density. We aimed to examine ethnic differences in skeletal phenotype in the context of pubertal growth and development in 279 adolescent males from Johannesburg, South Africa.We performed annual peripheral quantitative c...

We have previously observed sex-specific effects of maternal calcium supplementation on offspring childhood growth, in a rural Gambian population with habitually low calcium intake (~300 mg daily).1,2 There was no effect on maternal blood pressure, the primary outcome of the original trial.3 In this study, we aim to investigate effects on offspring blood pressure (BP) in the same cohort. We recruited children (205 female, 182 male) born following a random...

We have previously reported sex-specific effects of prepubertal calcium supplementation on the timing of adolescent growth,1 as well as sex-specific effects of maternal calcium supplementation on offspring childhood growth,2,3 in a rural Gambian population with habitually low calcium intake (~300 mg daily). In this study, we aim to investigate longer-term effects of maternal calcium supplementation on adolescent growth in same cohort. We recruited childre...

To understand differences in bone health between and within populations, it is crucial to characterise bone development during childhood and adolescence. Peak height velocity at age 16 and young adult height at age 23.5 years were recently reported in Gambian males accustomed to low calcium intake1. Our study aims to describe bone accrual after peak height velocity in the same population.We used peripheral quantitative computed tomography to m...

The prevalence of fractures in white children in South Africa is double that of black children (1). White males who fractured were shown to be more physically (2). The aim of this study was to compare the bone mass and geometry measures using peripheral quantitative computed tomography (pQCT) and dual energy x-ray absorptiometry (DXA) in black and white children with and without a history of fracture to determine the risk factors for fractures.Lifetime f...